Jai-Wei Gan Fishman, M.S.

Jai-Wei G. Fishman, M.S. is a patent agent specializing in the chemical, biological, pharmaceutical and biomedical fields.  Mrs. Fishman is an expert at completing patentability, infringement, clearance, freedom-to-operate and prior art searches of US and foreign patents, applications and publications.

Mrs. Fishman expertise includes conducting searches using many commercial databases, such as STN (chemical structure and literature), Westlaw, Delphion, ESP@CENET, Patent Abstracts of Japan, WIPO, and Google scholar.

Mrs. Fishman previously worked at The National Institutes of Health and Lockheed Martin Corp. Mrs. Fishman has published scientific papers in a variety of journals, including Neuron, Journal of Biological Chemistry and Molecular Pharmacology.

Mrs. Fishman has joined Capitol Patent & Trademark Law Firm as an independent consultant, patent agent and technology specialist.

Industry Experience: 

  • Lockheed Martin MSD Inc., Bethesda, MD            

As a Bioinfomatics Specialist, Mrs. Fishman managed the NIAID High Performance Computing infrastructure and Apple Bioinformatics Workgroup Cluster (BioCluster). Mrs. Fishman was responsible for the growth of the BioCluster program. One of her main responsibilities was to educate BioCluster users on high throughput analysis and molecular modeling. Mrs. Fishman was also responsible for establishing collaborations with NIH scientists.

  • National Institutes of Health, Bethesda, MD                     

As a biologist Mrs. Fishman:

  • Researched lipid metabolism in genetically modified animals and isolated a new protein for facilitating lipid metabolism in insects.
  • Analyzed free fatty acids of genetically modified mice using various different organic solvent and chemical agents. Designed peptide and purified antibodies of TIP47, LSDP-1 and LSDP-2.
  • Tested the immunological response from null mice using ELISA;
  • Characterized proteins TIP47, LSDP-1/LSDP-2 by the computational method, PAT domain.
  • Verified the protein TIP47 lipid binding function using Confocol imaging, Western blotting with affinity purified antibodies, and HeLa cell transfection.
  • Confirmed the LSDP-1/LSDP-2 lipid binding function by an over expression study of fat bodies targeting Drosophila melanogaster.
  • Eli Lilly, Indianapolis, Indiana                 
    As a research associate Mrs. Fishman conducted behavioral studies of muscarinic receptor knockout mice with experimental drugs and helped develop an antibody purification protocol for purification of various muscarinic receptors. Mrs. Fishman also conducted ligand binding studies with COS-7 cells that were transfected with different muscarinic binding receptor DNA constructs.

    PUBLICATIONS:
  • Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway, Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, Dorward H, Kimmel AR, Londos C. J Biol Chem. 2005 Dec 30; 280(52): 42841-7.
  • Functional Conservation for Lipid Storage Droplet Association Among Perilipin-, ADRP- And TIP47- Related Proteins In Mammals, Drosophila And Dictyostelium, Shinji Miura, Jai-wei Gan, Joseph Brzostowski, Michael J. Parisi, Charles J. Schultz, Constantine Londos, Brian Oliver, and Alan R. Kimmel. J Bol Chem, 2002 Aug 30; 277(35): 32253-7.
  • Muscarinic Induction Of Hippocampal Gamma Oscillations Requires Coupling Of The M1 Receptor To Two Mixed Cation Currents, A. Fisahn, M. Yamada, A. Duttaroy, Jai-wei Gan, CX. Deng, CJ. McBain, J. Wess. Neuron, 2002 Feb 14; 33(4): 615-24.
  • Evaluation Of Muscarinic Agonist-Induced Analgesia In Muscarinic Acetylcholine Receptor Knockout Mice, A. Duttaroy, J. Gomeza, Jai-Wei Gan, N. Siddiqui, A. Basile, W. Harman, P. Smith, C. Felder, A. Levey, and J. Wess. Mol Pharmacol, 200

EDUCATION:

Masters of Science in Bioinformatics awarded January 2005.

  • George Mason University, Fairfax, VA.
  • Course work included: Genomics, Biological Sequence Analysis, and Biological Data Modeling.

Bachelors of Science (Microbiology and Molecular Genetics) awarded March 1998.

  • University of Vermont, Burlington, VT.
  • Course work included: Molecular Biology, Genetics, Organic Chemistry, Immunology, Prokaryotic Genetics, Environmental Microbiology, Developmental Biology, Molecular Genetics, and Statistics


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